Diabetes Diabetic Foot Ulcers May Be Cure By A Vitamin A Compound
A compound of vitamin A called topical Retin-A also known as tretinoin, mainly used to treat acne problems, enhances the healing of foot ulcers in patients with diabetes, according to a report of the Archives of Dermatology.
Though previous studies showed that topical Retin-A was a bit helpful in enhancing wound healing in patients with diabetes and some results were discussed by different scientifics, a group of researchers tried to know if tretinoin really helped or not to these patients.
The research was carried out with 24 volunteers who had diabetic foot ulcers but who showed no evidence of infection or circulation problems in their extremities. Some patients were assigned to 4 weeks of daily treatment with topical 0.05 per cent tretinoin solution meanwhile the control group was assigned to a treatment with a saline solution. Both groups were assessed every 2 weeks.
The 22 volunteers who completed the study were affected by a total of 24 foot ulcers. 18 per cent of patients in the control group (2 of the 11 ulcers) and 46 per cent of patients in the treated group (6 of the 13 ulcers) achieved a complete healing at the end of 16 weeks. There was no statistical significance of adverse events, though some patients experienced mild pain at the ulcer site.
The researchers were pleased with the results, although they were a bit concerned because tretinoin irritates and they thought that the patients would become so irritated that they wouldn't be able to continue the research. However, this situation didn't seem to be a problem in most cases, as they explained.
A conclusion for the researchers was that they hope that diabetic foot clinics know about this and use Retin-A when other therapies that they use don't work
Though previous studies showed that topical Retin-A was a bit helpful in enhancing wound healing in patients with diabetes and some results were discussed by different scientifics, a group of researchers tried to know if tretinoin really helped or not to these patients.
The research was carried out with 24 volunteers who had diabetic foot ulcers but who showed no evidence of infection or circulation problems in their extremities. Some patients were assigned to 4 weeks of daily treatment with topical 0.05 per cent tretinoin solution meanwhile the control group was assigned to a treatment with a saline solution. Both groups were assessed every 2 weeks.
The 22 volunteers who completed the study were affected by a total of 24 foot ulcers. 18 per cent of patients in the control group (2 of the 11 ulcers) and 46 per cent of patients in the treated group (6 of the 13 ulcers) achieved a complete healing at the end of 16 weeks. There was no statistical significance of adverse events, though some patients experienced mild pain at the ulcer site.
The researchers were pleased with the results, although they were a bit concerned because tretinoin irritates and they thought that the patients would become so irritated that they wouldn't be able to continue the research. However, this situation didn't seem to be a problem in most cases, as they explained.
A conclusion for the researchers was that they hope that diabetic foot clinics know about this and use Retin-A when other therapies that they use don't work
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Diabetes úlceras del pie diabético Puede Ser Cure Por Un compuesto de vitamina A
Un compuesto de la vitamina A tópica llamada Retin-A también conocida como la tretinoína, que se utiliza principalmente para tratar problemas de acné, mejora la cicatrización de las úlceras del pie en pacientes con diabetes, según un informe de la revista Archives of Dermatology. Aunque estudios anteriores mostraron que Retin tópico -A era un poco útiles para mejorar la cicatrización de heridas en pacientes con diabetes y algunos resultados fueron discutidos por diferentes cientificos, un grupo de investigadores intentó saber si la tretinoína realmente ayudó o no a estos pacientes. La investigación se llevó a cabo con 24 voluntarios que tenían úlceras del pie diabético, pero que no mostraron evidencia de infección o problemas circulatorios en las extremidades. Algunos pacientes fueron asignados a 4 semanas de tratamiento diario con solución tópica 0,05 tretinoína por ciento mientras que el grupo de control fue asignado a un tratamiento con una solución salina. Ambos grupos fueron evaluados cada 2 semanas. Los 22 voluntarios que completaron el estudio se vieron afectados por un total de 24 úlceras en los pies. 18 por ciento de los pacientes en el grupo de control (2 de las 11 úlceras) y 46 por ciento de los pacientes en el grupo tratado (6 de las 13 úlceras) logra una curación completa al final de 16 semanas. No hubo significación estadística de los eventos adversos, aunque algunos pacientes experimentaron dolor leve en el lugar de la úlcera. Los investigadores se mostraron complacidos con los resultados, aunque eran un poco preocupado porque la tretinoína irrita y pensaban que los pacientes se volverían tan irritada que wouldn 't ser capaz de continuar con la investigación. Sin embargo, esta situación no parece ser un problema en la mayoría de los casos, según explicaron. Una conclusión de los investigadores fue que esperan que las clínicas del pie diabético saben sobre esto y usan Retin-A cuando otras terapias que utilizan no lo hacen . el trabajo
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